✪✪✪ Radiotherapy Research Paper
During his undergrad at University of California, Berkeley, Radiotherapy Research Paper used wavelet signal processing Radiotherapy Research Paper reconstruct audio signals at the Lawrence Berkeley National Laboratory. He enjoys collaborating with colleagues from Radiotherapy Research Paper fields and Radiotherapy Research Paper about the process of doing research more efficiently, in addition to doing research. Kawaguchi, N. Radiotherapy Research Paper case diagnosed with liposarcoma was sized After surgery, most Confucian Values In Imperial China Radiotherapy Research Paper patients had no complications and were Radiotherapy Research Paper from the hospital. Experiments were performed in duplicate.
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Advanced Materials , 33 37 : Frontispiece Cover Featured. Accounts of Materials Research , 2 7 : — Trends in Chemistry Cell Press , 3 7 : Invited Review. One-step and facile synthesis of peptide-like poly melphalan nanodrug for cancer therapy. Web of Science Highly Cited Paper. Nano-Micro Letters , Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics. Chemical Society Reviews , 50 4 : Angewandte Chemie International Edition , 60 13 : Biologically Modified Nanoparticles as Theranostic Bionanomaterials. Progress in Materials Science , Accounts of Chemical Research , 54 2 : — Matter Cell Press , 3 6 : Invited Preview.
In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment. Nature Reviews Materials , 5 11 : Matter Cell Press , 3 5 : Oral insulin delivery platforms: Strategies to address the biological barriers. Angewandte Chemie International Edition , 59 45 : Science Translational Medicine , 12 : eaay Nature Communications , 11 1 : Matter Cell Press , 3 1 : Nano Letters , 20 5 : Matter Cell Press , 2 2 : Journal of Materials Chemistry A , 8 1 : Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53 -deficient cancers to mTOR inhibition.
Science Translational Medicine , 11 : eaaw Advanced Science , 6 19 : Angewandte Chemie International Edition , 58 38 : KPC-luc cells were kindly provided by Dr. Edmund Waller Emory University. To measure KPC-luc tumor growth by bioluminescence imaging, mice were anesthetized inhalational isoflurane , followed by intraperitoneal i. In separate experiments, tumor-eradicated mice were re-challenged with the same cancer cells at different time points to test tumor resistance.
To perform RT, tumor-bearing mice were first anesthetized by ketamine Mice were monitored post-RT for discomfort and change in tumor volume. Mice that had eradicated their tumors following RT were maintained for an additional 6 months to 1. Liposomes without clodronate and Rat IgG isotype were used as controls. After washing, the labeled cells were examined by microscopy and read by flow cytometry.
To assess the efficacy of anti-tumor serum in vivo, WT mice were i. Tumors were excised without draining lymph nodes and were weighed. To perform IHC staining, the slides were treated with 0. Tissue sections were then counterstained with hematoxylin and mounted in a mounting medium. DAPI was used to stain nuclei. For flow cytometric analyses, cells were blocked with anti-FcR clone 2. Details of antibodies used in this study are shown in Supplementary Table 1.
Background hybridization by spiked-in negative controls was deducted. After washing, macrophage phagocytosis was analyzed microscopically or by FACS. Phagocytic indexes were quantified by the number of macrophages that ingested at least one target per macrophages analyzed. To isolate tumor-infiltrated Tc, tumor tissues were dissociated and cells were harvested. The collected tumor-conditioned medium 0. Control experiments were performed using medium without culturing tumor tissues. Cells were harvested on day 10 since T cells often had proliferated more than eight generations and had expanded over fold. The cells were added in the upper chamber of a well transwell device with filters 0. Cell samples were collected at various time points and the frequency of Tc therein was assessed by flow cytometry.
The culture was inspected daily by microscopy and T cell proliferation was generally apparent on day 3. Cell samples were also subjected to flow cytometric analysis of contents of Tc and Th cells. Subsequent rounds of T-cell infusion were performed at 3-day intervals MC38 or for 4 consecutive days in total KPC ; mice with a single or multiple tumor s received two or four rounds of T-cell infusion, respectively. All graphs and statistical analyses were generated and performed using Prism 7.
For analysis of overall survival Kaplan—Meier curves , Mantel—Cox log-rank test was used to determine statistical significance. Further information on research design is available in the Nature Research Reporting Summary linked to this article. Source data are available as a Source Data file. The remaining data are available within the Article, Supplementary Information or available from the authors upon request. Source data are provided with this paper. Baumann, M. Radiation oncology in the era of precision medicine. Cancer 16 , — Atun, R.
Expanding global access to radiotherapy. Lancet Oncol. Citrin, D. Recent developments in radiotherapy. Immunological mechanisms responsible for radiation-induced abscopal effect. Trends Immunol. Ngwa, W. Using immunotherapy to boost the abscopal effect. Cancer 18 , — Formenti, S. Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Antonia, S. Barker, H. The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence. Cancer 15 , — Twyman-Saint Victor, C. Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature , — Veillette, A.
Bian, Z. CdSirpalpha interaction and IL constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Natl Acad. USA , E—E Cassetta, L. Targeting macrophages: therapeutic approaches in cancer. Drug Discov. McLaughlin, M. Inflammatory microenvironment remodelling by tumour cells after radiotherapy. Cancer 20 , — Dorrington, M. Gold, L. Calreticulin: non-endoplasmic reticulum functions in physiology and disease. He, S. HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect.
Cell Death Dis. Galluzzi, L. Immunogenic cell death in cancer and infectious disease. Mandke, P. DNA Repair 83 , Dehne, N. Cancer cell and macrophage cross-talk in the tumor microenvironment. Lawrence, D. Decreased CD47 expression during spontaneous apoptosis targets neutrophils for phagocytosis by monocyte-derived macrophages. Early Hum. Jones, K. Radiation combined with macrophage depletion promotes adaptive immunity and potentiates checkpoint blockade. EMBO Mol. Chen, J. Han, C. Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling.
Zhu, Y. Tissue-resident macrophages in pancreatic ductal adenocarcinoma originate from embryonic hematopoiesis and promote tumor progression. Immunity 47 , — e Moynihan, K. Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses. Klichinsky, M. Human chimeric antigen receptor macrophages for cancer immunotherapy. Chao, M. Liu, X. Is CD47 an innate immune checkpoint for tumor evasion? CD47 blockade triggers T cell—mediated destruction of immunogenic tumors. Barkal, A. Ingram, J. Localized CD47 blockade enhances immunotherapy for murine melanoma.
USA , — Willingham, S. Weiskopf, K. CDblocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer. Soto-Pantoja, D. CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy. Cancer Res. Vanpouille-Box, C. Bronte, V. Effective genetic vaccination with a widely shared endogenous retroviral tumor antigen requires CD40 stimulation during tumor rejection phase. Yadav, M. Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Arginase-1 is neither constitutively expressed in nor required for myeloid-derived suppressor cell-mediated inhibition of T-cell proliferation.
Park, S. Nizard, M. Induction of resident memory T cells enhances the efficacy of cancer vaccine. Ozga, A. Simoni, Y. Rohaan, M. Adoptive cellular therapies: the current landscape. Virchows Arch. Juneja, V. PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity.Radiotherapy Research Paper Solution Of Water Pollution Close. Main Menu Utility Menu Search. I just repeat this cycle for much of the Radiotherapy Research Paper. Source Radiotherapy Research Paper Source Data.